1/2007Lyell’s syndrome – case report and literature review

DOROTA KRASOWSKA (Katedra i Klinika Dermatologii, Wenerologii i Dermatologii Dziecięcej Akademii Medycznej w Lublinie,Kierownik Kliniki: prof. dr hab. med. Grażyna Chodorowska)

Background
Lyell’s syndrome (toxic epidermal necrolysis – TEN) is an acute, life-threatening disease characterized by extensive epidermal sloughing and mucosal damage associated with multisystemic involvement reflecting the percentage of denuded area of affected skin. Drugs are proven causative factors of TEN, most commonly sulfonamides, anticonvulsants, nonsteroidal anti-inflammatory drugs and antibiotics.

Material and methods
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Results
The authors present a case report of Lyell’s syndrome in 18-year-old woman, accompanied by haemolytic anaemia, lymphopenia and liver insufficiency.

Key words: Lyell’s syndrome, toxic epidermal necrolysis, drug reaction.