3/2007Spirometry detecting COPD in patients from general practice primary care with family history of diseases involving obturation of the respiratory tract

KRZYSZTOF DOBOSZ (Poradnia Ogólna NZOZ Przychodnia Rejonowa „Ogrody” w Bydgoszczy; Kierownik: lek. stom. Andrzej Zieliński)

Background
The structure and function of the respiratory system is determined by multiple genes.

Material and methods
In Bydgoszcz, people at the age of > 18 were invited to undergo spirometry, free of charge, preceded by questionnaire research and the measurement of basic anthropometric parameters.

Results
A total of 1225 subjects participated. 292 (23.84%) of them reported the occurrence of chronic diseases involving obturation of the respiratory tract in their closest relatives, difference was not detected in their occurrence among patients from region 1 vs 2, men vs women and in age groups. COPD defined as FEV1/FVC ratio < 0.7, was detected in 188 subjects (15.34%). In 71 subjects (5.80%) COPD was mild (GOLD stage I) and in 99 (8.08%) moderate (stage II) and in 18 (1.47%) severe (stage III). Obturation was significantly (p < 001) more frequently diagnosed in people with family history (92/292 vs 96/933). An abnormal result of spirometry occurred always statistically more frequently in subjects having ill relatives, respectively in region 1 (54/147 vs 43/449; p < 001) and in 2 (38/145 vs 53/484; p < 001), in men (35/103 vs 35/388; p < 001) and in women (57/189 vs 61/545; p < 001) as well as in the younger (< 40 years of age; 12/40 vs 23/149; p < 05) and older age group (= 40 years of age; 80/251 vs 73/784; p < 001).

Key words: genetic load, family history, GOLD, COPD, mass screening, promoting health, primary care spirometry